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After studying painting at the Rhode Island School of Design, he moved into the field of photography. Klein shot high-profile advertising campaigns for various clients including Calvin Klein, D&G,Alexander McQueen and Nike and is a regular contributor to magazines including American and French Vogue, i-D, Numéro, W and Arena. His work has featured in numerous exhibitions, most recently at the Gagosian Gallery, California and the Brancolini Grimaldi Gallery in Florence. Klein is well known for his W Magazine editorials with Madonna , Tom Ford, Brad Pitt^[ and numerous others. He often works with Lighting Director David Devlin. Klein is represented by Todd Shemarya Artists for photography and Station Film for commercials. He shot the promotional pictures -including the album cover- of Britney Spears' third studio album, Britney, and recently directed the music video for Lady Gaga's single, "Alejandro."